Masterwork: Livewood Log, Wine, and Pixie Dust The base runes and their crafting ingredients are: There are six rune types, and four rune sizes you can make. You will find certain runes as loot or items to purchase from some vendors in your travels, but if you want a specific rune buff your best bet is to roll up your sleeves and make it yourself. Related: Ranking Larian Studios Games From Best To Worst Crafting Runes
These can be things like elemental resistances and damage bonuses.
They grant different buffs and bonuses depending on the type of rune. Runes, for those who haven't looked into them, are special items you can find or craft that slot into specific armor pieces or weapons.